Meketaten was the second daughter born to Akhenaten and Nefertiti. She had an older sister named Meritaten and four younger sisters named Ankhesenpaaten, Neferneferuaten Tasherit, Neferneferure and Setepenre. Tutankhaten was a half
Meketaten’s approximate year of birth is in or before year 4 of Akhenaten. Meketaten is first depicted on the walls of the Hut-benben temple dedicated to her mother Nefertiti in Thebes. Meketaten appears behind her older sister Meritaten in some of the later inscriptions, thought to date to year 4 or later. Further arguments to suggest Meketaten was born in or before year 4 come from the fact that her figure was added to one of the boundary stela recording events in year 4 and carved in year 5.
Meketaten moved to the new capital city Akhetaten with her family when she was still a small child. She is depicted in several of the tombs of the nobles in Amarna. Meketaten is depicted in the tomb of Ay holding a tray of gifts while wrapping one arm around her mother’s neck. Other monuments mentioning Meketaten include a stela from Heliopolis, a statue base from the Fayoum, and the tombs of Panehesy and Parennefer. Meketaten was depicted with her parents and sisters at the reception of foreign tributes – a ceremony dating to year 12 - that can be seen on several scenes in the private tombs in Amarna of high-ranking officials named Huya and High Priest Meryre II.
Meketaten died in approximately year 14 of Akhenaten. It is very likely that a plague swept across Egypt between Akhenaten's 12th and 15th regnal years, for many members of the royal family cease to be mentioned again; among them Queen Mother Tiye, Queen Nefertiti, Akhenaten's secondary wife Kiya, Meketaten and the two youngest princesses, Neferneferure and Setepenre. Meketaten's death could have resulted either from a plague, or from childbirth. The presence of a royal baby causes many to believe the young princess died in childbirth (in this case the father is most likely to had been Akhenaten himself, marrying his daughter), but it cannot be proven. An alternative interpretation suggested by van Dijk is that the child depicted in the scenes is the soul (the ka) of Meketaten.